aging-related disease

Repairing damaged DNA appears to drive aging by causing the loss of epigenetic information, but restoring that information reverses such effects, a study finds.

Damaged lysosomes are repaired by a lipid-based signaling pathway dubbed PITT that could be targeted to treat neurodegenerative disease, its discoverers say.

Researchers say there may be similar, human genes whose effects on lifespan vary by sex.

Immune cells deliver packages of telomeres to T cells, helping them retain their virus-fighting function over time, research suggests.

The Rockefeller University geneticist is tracing the full lifespan of individual cells to better understand how and why humans age.

Genes lacking a particular structure known as CpG islands tend to go haywire in older cells, a study finds, potentially contributing to key facets of aging. But it’s not yet clear if the relationship is causal.

Worms, flies, and yeast live longer if the fidelity of their protein-making machinery is improved, a study shows.

Mice and flies given the polyamine in their diet have increased brain cell metabolism and cognitive function, and epidemiological data hints at a similar benefit in humans.

Many major biopharmaceutical companies are developing or acquiring drugs that target the NLRP3 inflammasome, a large intracellular complex that researchers say can spark inflammation and stoke diseases of lifestyle and aging.

Researchers repaired what is otherwise irreversible damage in the animals’ ocular neurons, by activating transcription factors ordinarily used to generate induced pluripotent stem cells.

The test will be a cheaper and more accessible alternative to currently available diagnostic tools, researchers say.

A handful of clinical trials are underway to find out whether drugs that target senescent cells can slow the ravages of old age.

The accumulation of zombie-like cells seems to accelerate aging and promote aging-related disease. Researchers are trying to figure out how.

The agency warns that plasma treatments costing thousands of dollars, which supposedly treat the infirmities of old age, have not been proven “safe or effective.”

Numerous cellular changes underlie the decline of muscle mass and strength in the elderly.

Meet some of the people featured in the September 2018 issue of The Scientist.

Researchers untangle the multifarious nature of muscle aging. So far, the only reliable treatment is exercise.

Genetic adaptations for human brain development also make us vulnerable to Alzheimer’s disease, according to a new study.